EPO admits patent mistake
نویسندگان
چکیده
منابع مشابه
Emerging EPO and EPO receptor regulators and signal transducers.
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...
متن کاملCorrecting Darwin's Other Mistake
Review of: Experimental Evolution: Concepts, Methods and Applications of Selection Experiments. Edited by Theodore Garland, Jr. and Michael R. Rose, 2009. Univ. of California Press, Berkeley, California. 752 pp. Hardcover ISBN 9780520247666, $75.00; Paperback ISBN 9780520261808, $45.00. It has become a cliché to say that evolutionary biologists need multiple types of approaches to be effective....
متن کاملAutocrine stimulation by erythropoietin (Epo) requires Epo secretion.
Erythropoietin (Epo) autocrine stimulation has been implicated in erythroblastic leukemia. To examine whether this stimulation could occur intracellularly, we developed Epo autocrine models of stimulation in the human pluripotent UT-7 cell line. Retroviral expression of Epo totally abolished the growth factor requirement of UT-7 cells. Autonomous proliferation was not cell density-dependent and...
متن کاملSelected anti-Epo receptor antibodies predict Epo receptor expression.
In an article recently published in Blood, Elliott et al 1 reported that commercially available anti–erythropoietin receptor (anti-EpoR) antibodies are hardly usable to predict EpoR expression because of their low specificity and affinity. Although we agree with the authors that many of these antibodies work poorly, we strongly disagree with them concerning 2 main points: (1) the ability of San...
متن کاملAnti-Epo receptor antibodies do not predict Epo receptor expression.
Investigators using anti-EpoR antibodies for immunoblotting and immunostaining have reported erythropoietin receptor (EpoR) expression in nonhematopoietic tissues including human tumors. However, these antibodies detected proteins of 66 to 78 kDa, significantly larger than the predicted molecular weight of EpoR (56-57 kDa). We investigated the specificity of these antibodies and showed that the...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2000
ISSN: 1087-0156,1546-1696
DOI: 10.1038/74354